Prophylactic cranial irradiation in SCLC
نویسندگان
چکیده
منابع مشابه
Models support prophylactic cranial irradiation.
In this issue of the Journal of Clinical Oncology, Lee et al present a rather unique and useful statistical interpretation of the waxing question of prophylactic cranial irradiation (PCI) for patients with small-cell lung cancer (SCLC). The concept of PCI for SCLC has its origins in the comparison of the behavior of this disease with childhood leukemia, a disease that is essentially systemic in...
متن کاملProphylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group.
BACKGROUND Prophylactic cranial irradiation reduces the incidence of brain metastasis in patients with small-cell lung cancer. Whether this treatment, when given to patients in complete remission, improves survival is not known. We performed a meta-analysis to determine whether prophylactic cranial irradiation prolongs survival. METHODS We analyzed individual data on 987 patients with small-c...
متن کاملProphylactic Cranial Irradiation in Extensive Small-Cell Lung Cancer
From the Departments of Radiation Oncology (B.S., S.S.) and Pulmonary Diseases (P.P.), VU University Medical Center, Amsterdam; and Arnhem’s Radiotherapeutisch Instituut, Arnhem (G.K.) — both in the Netherlands; Christie Hospital, Manchester (C.F.-F.); University of Dundee Ninewells Hospital, Dundee (E.R.); Cookridge Hospital, Leeds (M.S.); and Weston Park Hospital, Sheffield (M.H.) — all in th...
متن کاملProphylactic cranial irradiation in small cell lung cancer.
The Brain is one of the common relapse sites in small cell lung cancer because of isolation from chemotherapeutic agents by the blood-brain barrier. Prophylactic cranial irradiation (PCI) is expected to reduce brain relapse and increase the survival rate. PCI prolonged the survival in only 10-20% of patients with small cell lung cancer after complete response. Most randomized trials demonstrate...
متن کاملProphylactic Cranial Irradiation for Extensive Small-Cell Lung Cancer.
Small-cell lung cancer (SCLC) has a high predilection for metastasizing to the brain after chemotherapy. This has been blamed on the blood-brain barrier, which prevents chemotherapy from penetrating into the brain, thus creating a sanctuary site. It has been estimated that up to three quarters of patients with SCLC will eventually develop brain metastases. This led investigators to administer p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Translational Lung Cancer Research
سال: 2021
ISSN: 2218-6751,2226-4477
DOI: 10.21037/tlcr-2020-rtm-05